A one-pot approach to neoglycopeptides using orthogonal native chemical ligation and click chemistry.
نویسندگان
چکیده
The powerful combination of native chemical ligation and click chemistry has been used to affect a one-pot synthesis of neoglycopeptides from propargyl-containing peptides using GalNAc-N(3) as the glycan component. A versatile chemical toolkit for the fully convergent synthesis of neoglycoproteins using click chemistry, native chemical ligation, and kinetically controlled ligation is thus demonstrated.
منابع مشابه
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عنوان ژورنال:
- Organic letters
دوره 11 22 شماره
صفحات -
تاریخ انتشار 2009